RAF Typhoon fighter aircraft have operated alongside France's air force in a coordinated attack targeting an subterranean weapons facility in Syria used by the IS group, per a report from the UK's MoD.
The location, identified by reconnaissance, was believed to be housing weapons and explosive materials, the announcement noted, and was situated in hills just to the north of the historic site of Palmyra in Syria's central region.
"Our aircraft used laser-guided Paveway IV weapons to strike a series of entry passages leading to the site... initial indications indicate the strike was effective," the ministry announced.
There was no evidence of any civilian casualties in the strike on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
Daesh - referred to as the so-called Islamic State - enforced militant control over large swathes of Iraq and Syria prior to its 2019 collapse.
"This operation shows British leadership, and determination to stand shoulder to shoulder with allied nations, to stamp out any revival of Daesh and their violent and radical beliefs in the area," Britain's Defence Chief the Defence Secretary said.
UK warplanes have conducted patrols over Syria to "forestall any attempted comeback" of Islamic State after its routing at the battle of Baghuz in 2019, the ministry said.
"I want to thank every member of British forces involved in this strike for their professionalism and their valour," the Defence Secretary commented. "They were among numerous UK service members on duty over the festive period. This mission, to take out dangerous terrorists who endanger our safety, demonstrates how our armed forces are ready to step up, continuously, ensuring Britain's security domestically and powerful internationally."
Last December, the United States armed forces executed what it termed a "large-scale strike" on IS targets in the country, following an attack resulted in the deaths of two American soldiers and a civilian interpreter in the Palmyra area.
The UN reports IS still maintains an estimated 5,000 to 7,000 fighters in Syria and Iraq.